Research

We use dynamics and imaging to understand behavior of cells and tissues.

Brain biomechanics and mechanics of soft tissues and biomaterials

Objectives: To better understand traumatic brain injury (TBI), and improve the prevention, diagnosis and therapy for TBI. To better understand brain development, and improve diagnosis and management of developmental disorders. 

  • Tagged MR imaging of the brain
  • Magnetic resonance elastography of the brain
  • Waves in anisotropic tissues and fibrin gels
  • MRI of developing brain
  • Modeling and simulation of brain mechanics
Tagged MRI of the brain during mild angular acceleration of the skull

Tagged MRI of the brain during mild angular acceleration of the skull

 

Oscillations and waves in cilia and flagella

Objectives: To answer the fundamental question: how do cilia and flagella beat? The answer will enable us to improve the diagnosis and treatment of cilia-related disorders or develop new micro-scale biomimetic devices.

  • Video microscopy and waveform analysis
  • Nano-scale imaging of the flagellar cytoskeleton
  • Mathematical modeling of cilia and flagella
  • Stability analysis and simulation of flagella/cilia models

Analysis of Chlamydomonas cilia waveform (Louis Woodhams)